RapamycinFungusV1, Main, Exploration, bibRecord, 000194

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.

Identifieur interne : 000194 ( Main/Exploration ); précédent : 000193; suivant : 000195

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.

Auteurs : Chunsun Jiang [États-Unis] ; Chengfeng Bi [États-Unis] ; Xiaoxing Jiang [États-Unis] ; Tian Tian [États-Unis] ; Xin Huang [États-Unis] ; Cheng Wang [États-Unis] ; Mario R. Fernandez [États-Unis] ; Javeed Iqbal [États-Unis] ; Wing C. Chan [États-Unis] ; Timothy W. Mckeithan [États-Unis] ; Robert E. Lewis [États-Unis] ; Kai Fu [États-Unis]

Source :

British journal of haematology [ 1365-2141 ] ; 2019.

RBID : pubmed:30198569

Descripteurs français

English descriptors

KwdEn :
- AMP-Activated Protein Kinases (genetics), AMP-Activated Protein Kinases (metabolism), Cell Line, Tumor (MeSH), Humans (MeSH), Lymphoma, Mantle-Cell (genetics), Lymphoma, Mantle-Cell (metabolism), Lymphoma, Mantle-Cell (pathology), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 1 (metabolism), MicroRNAs (genetics), MicroRNAs (metabolism), Neoplasm Proteins (genetics), Neoplasm Proteins (metabolism), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), RNA, Neoplasm (genetics), RNA, Neoplasm (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , genetics : AMP-Activated Protein Kinases, Mechanistic Target of Rapamycin Complex 1, MicroRNAs, Neoplasm Proteins, Protein-Serine-Threonine Kinases, RNA, Neoplasm, TOR Serine-Threonine Kinases.
- chemical , metabolism : AMP-Activated Protein Kinases, Mechanistic Target of Rapamycin Complex 1, MicroRNAs, Neoplasm Proteins, Protein-Serine-Threonine Kinases, RNA, Neoplasm, TOR Serine-Threonine Kinases.
- genetics : Lymphoma, Mantle-Cell.
- metabolism : Lymphoma, Mantle-Cell.
- pathology : Lymphoma, Mantle-Cell.
- Cell Line, Tumor, Humans, Signal Transduction.

DOI: 10.1111/bjh.15591
PubMed: 30198569

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000458
to stream Main, to step Curation: 000458

Le document en format XML

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<term>AMP-Activated Protein Kinases (metabolism)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lymphoma, Mantle-Cell (genetics)</term>
<term>Lymphoma, Mantle-Cell (metabolism)</term>
<term>Lymphoma, Mantle-Cell (pathology)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (metabolism)</term>
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<term>Neoplasm Proteins (metabolism)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>RNA, Neoplasm (genetics)</term>
<term>RNA, Neoplasm (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (génétique)</term>
<term>AMP-Activated Protein Kinases (métabolisme)</term>
<term>ARN tumoral (génétique)</term>
<term>ARN tumoral (métabolisme)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Lymphome à cellules du manteau (anatomopathologie)</term>
<term>Lymphome à cellules du manteau (génétique)</term>
<term>Lymphome à cellules du manteau (métabolisme)</term>
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<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines tumorales (génétique)</term>
<term>Protéines tumorales (métabolisme)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
<term>microARN (génétique)</term>
<term>microARN (métabolisme)</term>
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<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>MicroRNAs</term>
<term>Neoplasm Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>RNA, Neoplasm</term>
<term>TOR Serine-Threonine Kinases</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>MicroRNAs</term>
<term>Neoplasm Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>RNA, Neoplasm</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphome à cellules du manteau</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphoma, Mantle-Cell</term>
</keywords>
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<term>ARN tumoral</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Lymphome à cellules du manteau</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines tumorales</term>
<term>Sérine-thréonine kinases TOR</term>
<term>microARN</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term>
<term>ARN tumoral</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Lymphome à cellules du manteau</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines tumorales</term>
<term>Sérine-thréonine kinases TOR</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphoma, Mantle-Cell</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Transduction du signal</term>
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<Title>British journal of haematology</Title>
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<AffiliationInfo><Affiliation>Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Xiaoxing</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Iqbal</LastName>
<ForeName>Javeed</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Wing C</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, City of Hope Medical Center, Duarte, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McKeithan</LastName>
<ForeName>Timothy W</ForeName>
<Initials>TW</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, City of Hope Medical Center, Duarte, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lewis</LastName>
<ForeName>Robert E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 CA090400</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>09</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Br J Haematol</MedlineTA>
<NlmUniqueID>0372544</NlmUniqueID>
<ISSNLinking>0007-1048</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C568997">MIRN17-92 microRNA, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009363">Neoplasm Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012334">RNA, Neoplasm</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber>
<NameOfSubstance UI="C109790">STK11 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.31</RegistryNumber>
<NameOfSubstance UI="D055372">AMP-Activated Protein Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055372" MajorTopicYN="N">AMP-Activated Protein Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020522" MajorTopicYN="N">Lymphoma, Mantle-Cell</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009363" MajorTopicYN="N">Neoplasm Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012334" MajorTopicYN="N">RNA, Neoplasm</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">STK11/AMPK/TSC pathway</Keyword>
<Keyword MajorTopicYN="Y">cell metabolism</Keyword>
<Keyword MajorTopicYN="Y">mTORC1</Keyword>
<Keyword MajorTopicYN="Y">mantle cell lymphoma</Keyword>
<Keyword MajorTopicYN="Y">miR-17˜92 cluster</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>9</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>9</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30198569</ArticleId>
<ArticleId IdType="doi">10.1111/bjh.15591</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Floride</li>
<li>Nebraska</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Nebraska"><name sortKey="Jiang, Chunsun" sort="Jiang, Chunsun" uniqKey="Jiang C" first="Chunsun" last="Jiang">Chunsun Jiang</name>
</region>
<name sortKey="Bi, Chengfeng" sort="Bi, Chengfeng" uniqKey="Bi C" first="Chengfeng" last="Bi">Chengfeng Bi</name>
<name sortKey="Chan, Wing C" sort="Chan, Wing C" uniqKey="Chan W" first="Wing C" last="Chan">Wing C. Chan</name>
<name sortKey="Fernandez, Mario R" sort="Fernandez, Mario R" uniqKey="Fernandez M" first="Mario R" last="Fernandez">Mario R. Fernandez</name>
<name sortKey="Fu, Kai" sort="Fu, Kai" uniqKey="Fu K" first="Kai" last="Fu">Kai Fu</name>
<name sortKey="Huang, Xin" sort="Huang, Xin" uniqKey="Huang X" first="Xin" last="Huang">Xin Huang</name>
<name sortKey="Iqbal, Javeed" sort="Iqbal, Javeed" uniqKey="Iqbal J" first="Javeed" last="Iqbal">Javeed Iqbal</name>
<name sortKey="Jiang, Xiaoxing" sort="Jiang, Xiaoxing" uniqKey="Jiang X" first="Xiaoxing" last="Jiang">Xiaoxing Jiang</name>
<name sortKey="Lewis, Robert E" sort="Lewis, Robert E" uniqKey="Lewis R" first="Robert E" last="Lewis">Robert E. Lewis</name>
<name sortKey="Mckeithan, Timothy W" sort="Mckeithan, Timothy W" uniqKey="Mckeithan T" first="Timothy W" last="Mckeithan">Timothy W. Mckeithan</name>
<name sortKey="Tian, Tian" sort="Tian, Tian" uniqKey="Tian T" first="Tian" last="Tian">Tian Tian</name>
<name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name>
</country>
</tree>
</affiliations>
</record>

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The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.

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